Case-based discussion of the acute hepatic porphyrias: Updates on pathogenesis, diagnosis and management

Liver International, March 2025

Using a case-based format, this publication provides an update on the pathogenesis, diagnosis and treatment of the acute hepatic porphyrias (AHPs) based on literature review and clinical experiences.

The acute hepatic porphyrias (AHPs) include three autosomal dominant disorders, acute intermittent porphyria (AIP), variegate porphyria (VP) and hereditary coproporphyria (HCP), and the ultra-rare autosomal recessive 5-aminolevulinic acid dehydratase-deficient porphyria (ADP).

Authors

Manisha Balwani, Siobán Keel, Peter Meissner, Mark Sonderup, Penelope Stein, Makiko Yasuda